ODCs

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1 OMIM reference -
1 associated gene
15 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 3

3 OMIM references -
3 associated genes
10 signs/symptoms

Fibular aplasia - complex brachydactyly

Multiple synostoses syndrome

Citations in the biomedical literature:

Fibular aplasia - complex brachydactyly		Multiple synostoses syndrome
	Synonym(s): - Du Pan syndrome		Synonym(s): - Deafness - symphalangism syndrome, Hermann type - Facio-audio-symphalangism - Symphalangism - brachydactyly - WL syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare otorhinolaryngologic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 3 OMIM references - No MeSH references


COMMON SIGNS	- Restricted joint mobility / joint stiffness / ankylosis - Short hand / brachydactyly - Simian crease / transverse / unique palmar crease

Fibular aplasia - complex brachydactyly		Multiple synostoses syndrome
	Very frequent - Autosomal recessive inheritance - Carpal bones fusion / synostosis - Epiphyseal anomaly - Hip dislocation / dysplasia / coxa valga / coxa vara / coxa plana - Narrow nasal bridge - Radius anomaly / absence / agenesis / hypoplasia / abnormal radial ray - Short limbs / micromelia / brachymelia - Short stature / dwarfism / nanism - Tarsal anomaly / fusion / synostosis - Thumb anomalies (excluding hypoplasia) - Tibia anomaly (excluding short) / absence / agenesis / hypoplasia / tibial ray anomaly - Ulnar / cubital anomaly / absence / agenesis / hypoplasia / abnormal ulnar / cubital ray		Very frequent - Autosomal dominant inheritance - Conductive deafness / hearing loss - Symphalangy of fingers Frequent - Broad / bifid thumb - Cone epiphyses / epiphysis Occasional - Facial structural asymmetry / facial hemiatrophy / facial hemihypertrophy - Nails anomalies